Effect of Age on Working Memory Performance and Cerebral Activation after Mild Traumatic Brain Injury: A Functional MR Imaging Study

Our results suggested better neural plasticity after mild traumatic brain injury (MTBI) in younger patients in a 6-week follow-up period after initial imaging, whereas MTBI may have a more profound and lasting effect in older patients, who apparently have less neural plasticity function than do younger patients.


To evaluate the age effect on working memory (WM) performance and functional activation after mild traumatic brain injury (MTBI).

The different manifestations of postconcussion symptoms at functional MR imaging between younger and older patients confirmed the important role of age in the activation, modulation, and allocation of WM processing resources after MTBI. These findings also supported that younger patients have better neural plasticity and clinical recovery than do older patients.
David Yen-Ting Chen, Hui-Ling Hsu, Ying-Sheng Kuo, Changwei Wesley Wu, Wen-Ta Chiu, Feng-Xian Yan, Wei-Shuan Wang, Chi-Jen Chen and Ying-Chi Tseng
Address correspondence to Y.C.T. (e-mail: x2mickey@yahoo.com.tw).